• Experience in working with SOD1 mice (a transgenic mouse model of ALS) and with c57bl mice. 27. Transfer 1 male and thereafter 1 female into the breeding cage by holding them by the tail (Step 3.3). • Detailed records for breeding clonies are critical to the success of oneo s colony. The Jackson Laboratory's Colony Management System (JAX-CMS) for research mouse colonies . Course Manual and courses - The Jackson Laboratory has a great free PDF manual about breeding mice that can be downloaded: Breeding Strategies for Maintaining Mice Colonies. Colonies of Laboratory Mice. SURPLUS) Author: Thomas Gomez Last modified by: Windows User Created Date: 9/18/2009 12:02:43 AM Other titles: 4.6 Breeding and Weaning Issues 4.6.1 A standard-sized filter-top mouse cage (75 square inch floor space) can house up to 5 adult mice. These techniques have. Title: Breeding and Weaning of Mice and Rats Table 2. Translated from : Breeding strategies for maintaining colonies of laboratory mice, The Jackson Laboratory Resource Manual, 2009. Th ey are safe, reliable, economical, effi cient, and ensure . In either case, CM, AI integration and open software integration. The webinar will demonstrate how applying best practice can help you produce well-controlled and reproducible research and get the most out of Using both sexes of mice can actually reduce the cost of maintaining a mouse colony . Strain rederivation and cryopreservation services Th ey are safe, reliable, economical, effi cient . Breeding information services. If you will be breeding animals and do not already have an approved breeding protocol on file . Bar Harbor, ME 04609 USA, The Jackson Laboratory; 2007. Lift the mouse by the tail for 2-3 s. If the mouse needs to be held longer, hold onto the tail and place the mouse in the cupped hand maintaining the hold on the tail. Selected for genetically standardized nomenclature. [Google Scholar] 4. Pro: Th 'Example of a spreadsheet is on our website . Evidence should trump intuition by preferring inbred strains to outbred stocks in preclinical research. Both investigative and veterinary staffs monitor the health and well-being of mice that are used in research. Mouse Strain Divergence. Then the fertilized egg (embryo) or eggs (embryos) are transferred to a uterus. That number assumes a breeding colony of 10-12 pair matings with a 6- to 8-month reproductive life span, around 90% productive matings, replacement of breeders, and no unusual mutant infertility or mortality. The Jackson Laboratory Handbook on Genetically Standardized Mice . If moving pups aged P0-P7, scoop the entire nest up with a gloved hand to transfer pups with minimal disturbance. Indeed, this level of responsibility and care is mandated by the Public Health Service based on the Guide for the Care and Use of Laboratory Animals (National Research Council. That mortality is higher in primiparous females is a widespread view in laboratory animal breeding and the Jackson Laboratory report that C57BL/6J females frequently lose their first litter ( Breeding Strategies for Maintaining Colonies of Laboratory Mice 2007 ). A Jackson Resource Manual. • Knowledge in breeding strategies in maintaining colonies of laboratory mice. Mouse Colony Breeding Costs (Adapted from: "Breeding Strategies for Maintaining Colonies of Laboratory Mice", The Jackson Laboratory, 2009) Maintenance cost per mouse cage (average of US academic institutions in 2009): US $550 per year, US $10.60 per week ABR cage rate (2018) $10.70 per week ($556.40 per year) Cost of Maintenance Breeding This manual describes breeding strategies and techniques for. (a) performs special husbandry needs required for animal experiments and disease control such as managing valuable colonies of transgenic mice, gene knockout and immunodeficient mice; responsible for establishing rodent breeding colonies, maintaining records, providing technical support involving identification, sampling for DNA analysis . Lambert R (2007) Breeding Strategies for Maintaining Colonies of Laboratory Mice. Single-sex housing costs are often greater for male mice, due to aggressive behavior in group-housed males . Table 3. Th ese techniques have been developed and used by Th e Jackson Laboratory for over 75 years. Standardization of nomenclature: • Aids in scientific communication • Link gene to specific alleles and genetic background Adapted from Jackson Lab, 2007, "Breeding Strategies for Maintaining Colonies of Laboratory Mice." TOTAL NUMBER OF BREEDING MICE NEEDED (INCL. The importance of rigorous data collection and record keeping. Protocol Requirements. Hemizygous: Possessing an unpaired allele at a strong locus. Some smaller strains may need an. The Coat Colors of Mice: A model for Mammalian Gene Action and Interaction by Willys K Silver. These techniques have been developed and used by The Jackson Laboratory for nearly 80 years. Breeding Strategies for Maintaining Colonies of Laboratory Mice. Factors affecting mouse breeding performance. Reproductive characteristics for most inbred strains of laboratory mice. [Cited 1 July 2013]. Relax and handle the mice gently. It's important to determine the number of breeding pairs you need to supply sufficient mice for your experiments. Although mice breed readily when left to themselves, it is helpful to have a working knowledge of They are safe, reliable, economical, efficient . Breeding Strategies for Maintaining Colonies of Laboratory Mice - A Jackson Laboratory Resource Manual, . To verify the health of laboratory mice I went to Jackson Laboratory-the "most important supplier of lab animals to science"-and viewed their "Breeding Strategies for Maintaining Colonies of Laboratory Mice." The manual claims that the breeding strategies that are used to create inbred lab mice are: When breeding in the animal facility, researchers are able to manipulate the genetics of the animals, time the pregnancies to meet the needs of the research, and work with embryos and neonates as required. 246 13.D. • The recommended breeding strategy for rodents is monogamous pairs (1 male and 1 female) . Basis: Recommendations for housing laboratory rodents are based on the 2010 edition of the NIH Guide for the Care and Use of Laboratory Animals (the Guide, pp. nomenclature tutorial, the mouse in animal genetics and breeding research free, breeding strategies for maintaining colonies of laboratory, the mouse in animal genetics and breeding research , mouse in animal genetics and breeding research the, laboratory mouse wikipedia , the mouse in biomedical research volume 1 2nd edition, the use of mice . keeping in mind the special needs of investigators maintaining transgenic mouse breeding colonies. Breeding Strategies for Maintaining Colonies of Laboratory Mice: A Jackson Laboratory Resource Manual. • To reduce over-breeding and excessive per diem costs by maintaining wellcalculated, - managed and efficient mouse colonies • To reduce laboratory costs associated with labor needed to maintain mouse colonies • To free up post-doctorate researchers time for conducting research instead of maintaining mouse colonies The Mouse In Animal Genetics And Breeding Research Laboratory mouse Wikipedia April 22nd, 2019 - The laboratory mouse is a small mammal of the order Rodentia which is bred and used for scientific research Laboratory mice are usually of the species Mus musculus They are the most commonly used mammalian Preventing genetic contamination and minimizing genetic drift • If you breed laboratory mice, it is imperative that you follow breeding and colony management practices that prevent genetic contamination and minimize the effects of genetic drift. BREEDING STRATEGY A justification for a breeding colony should include: • The reason for maintaining a breeding colony of the strains that will be listed in the application form. Th ese techniques have been developed and used by Th e Jackson Laboratory for over 75 years. Investigators maintaining breeding colonies exclusively to preserve a genetic line of rodents should consider other strategies such as cryopreservation of ova, sperm and/or embryos. This course provides training in the theory and practice of maintaining mouse colonies for research. 4.1. The Jackson Laboratory recommends mouse trio breeding groups, stating that "Most Refreshing the background strain to avoid genetic drift The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position. . propagate. The purpose for this regulation is to effectively establish and maintain rodent breeding colonies at North Carolina Central University (NCCU). The laboratory mouse (Mus musculus) has been employed in biomedical research for its amenability to genetic modification.The genetic modifications have enabled the development of new mouse strains for studying diverse diseases. MOUSE BREEDING COLONY MANAGEMENT SOP 608.02 - Mouse Breeding Colony Management Page 1 of 4 . Generally, laboratory mice will reach sexual maturity at approximately 6 weeks of age, although females may . 1) Some mice breed better when fed diets high in fat (11% compared to 4%) v. Health 1) Laboratory mice stop breeding if they are unhealthy. A Jackson Laboratory Resource Manual. For convenience we have made the following information publicly available: Table 1. Workshop on Colony Management and Biomethods. maintaining colonies of laboratory, amiya ranjan sahu ph d animal genetics and breeding, the history of breeding mice for science begins with a, the mouse in animal genetics and breeding research, why use the mouse in research facts yourgenome org, a mouse by any other name nomenclature tutorial, laboratory mouse wikipedia, learn about being an 80 years. At the end of the MiniCourse, you will be able to size your experimental mouse colonies. Breeding Strategies for Maintaining Colonies of Laboratory Mice - A Jackson Laboratory Resource Manual Appendix B of the ILAR Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research (2003) - provides guidance for estimating the number of animals required to maintain a mouse breeding colony The proper establishment of these breeding colonies will result in a higher offspring yield and the increased survival of pups. AI in the mouse may be especially useful for breeding of transgenic or mutant mice with fertility problems, expansion of mouse colonies, and as an alternative to in vitro fertilization. Conditions detrimental to breeding include ulcerative dermatitis. The laboratory mouse the health status and its influence on breed- was established in the early years of the twen- ing efficiency is exemplified. The Jackson Laboratory. Biology of the Laboratory Mouse by The Staff of The Jackson Laboratory. 10) Maintaining the Genetic Integrity of Colonies 30. OBJECTIVE: Drexel University Institutional Animal Care and Use Committee (IACUC) has established this policy to provide information for the proper maintenance of mouse breeding colonies.. RESPONSIBILITY: Principal investigators (PI), their designated staff and University Laboratory Animal Resources (ULAR) staff who are managing mouse breeding . The . Breeding Strategies for Maintaining Colonies of Laboratory Mice: A Jackson Laboratory Resource Manual, The Jackson Laboratory. Abstract. Conditions detrimental to breeding include ulcerative dermatitis. Origins of Inbred Mice Edited by Herbert Morse III. A note to our readers from the editors… \爀䘀漀爀 漀瀀琀椀洀愀氀 瘀椀攀眀椀渀最 漀昀 瀀愀最攀 氀愀礀漀甀琀 椀渀 䄀搀漀戀攀 䄀挀爀漀戀愀琀Ⰰ 眀攀 爀攀挀漀洀洀攀渀搀 琀栀攀 昀漀氀氀漀眀椀渀最㨀 唀渀搀敜ഀ爀 琀栀攀 嘀椀攀眀 洀攀渀甀 . o Breeding errors? The Jackson . 1,100 mice can be required for quantitative trait loci analysis using analysis of F2 progeny. Foremost among these critical points is that animal husbandry practices, including well . Mouse Nomenclature. Investigators maintaining colonies simply to preserve a genetic line of rodents should consider other conservation strategies such as cryopreservation of ova, sperm and embryos. Breeding Strategies for Maintaining Colonies of Laboratory Mice A Jackson Laboratory Resource Manual This manual describes breeding strategies and techniques for maintaining colonies of laboratory mice. -Drexel University . 4.6.2 Accepted breeding schemes at FIU include monogamous (one male, one female), and trio (one male, two . Manual Th is manual describes breeding strategies and techniques for maintaining colonies of laboratory mice. This chapter will provide information on mouse genetics, their nomenclature, and different strategies of breeding. A Jackson Laboratory Resource Manual, 2007: The Jackson Laboratory. Some costs may be expected to decrease, however. The webinar recording is now available to watch online. Th ey are safe, reliable, economical, effi cient, and ensure that. Festing MF. Grasping the mouse by the base of the tail will give you greater control. e. . Breeding Strategies for Maintaining Colonies of Laboratory Mice . Due to naturally occurring genetic drift, an inbred mouse strain will diverge into a genetically distinct substrain if its breeding colony is separated from the parental breeding colony for more than 20 generations of breeding (i.e., 10 generations in the parent colony plus the 10 that simultaneously pass in the sub-colony*). Although . 2011).The Guide is "intended to assist investigators in fulfilling their obligation to plan . INTRODUCTION. Strategies for maximizing productivity of a breeding colony. Participants completing this course will obtain a thorough understanding of colony management best practice that incorporates the latest developments and trends in the use of the laboratory mouse in . Breeding Strategies for Maintaining Colonies of Laboratory April 20th, 2019 - Th is manual describes breeding strategies and techniques for maintaining colonies of laboratory mice Th ese techniques have been developed and used by Th e Jackson Laboratory for over 75 years Th ey are safe reliable A Jackson Laboratory resource manual, The Jackson Laboratory. Breeding Strategies for Maintaining Colonies of Laboratory Mice. Permission to establish a breeding colony is granted on a case-by-case basis, with the most acceptable reasons for requiring a breeding colony listed below: Breeding Strategies for Maintaining Colonies of Laboratory Mice - A Jackson Laboratory Resource Manual Appendix B of the ILAR Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research (2003) - provides guidance for estimating the number of animals required to maintain a mouse breeding colony Maintaining a breeding colony of mice is one method of generating and then ensuring an available supply of experimental subjects with desired characteristics. Breeding Strategies for Maintaining Colonies of Laboratory Mice, The Jackson Laboratory. Watch this video to learn about: The fundamentals of mouse reproduction. The use of continuous trio breeding groups can result in a higher breeding efficiency by permitting breeding at the first post-partum estrus and facilitating pup survival through cross fostering. The Jackson Laboratory 1 Th e laboratory mouse is playing an increasingly important role in biomedical research. Tailless mice may be grasped by the scruff of the neck. Mouse Breeding Policy . To be sure, selecting the appropriate preclinical model for the question of interest is central to the . (check genotypes) Expect changes on a new background o Keep previous generations while evaluating Refresh colony every ~ 10 generations o Replace breeders from a trusted vendor o Backcross to inbred or F1 hybrid parent Maintain pedigreed colonies o Filial (sister x brother) matings A. It is worth reiterating some of the important points described in these reviews that pertain to traditional strategies for maintaining genetically defined inbred or outbred (Nomura 1999) stocks of mouse and rat colonies and testing their genetic background. During this seminar, we will discuss strategies to save cost and time by efficiently managing mouse colonies. Summary The Biomedical Research Core Facilities (BRCF), as part of the Medical School's Office of Research (OoR), has . 56-58). Wisconsin Alumni Research Foundation, Laboratory CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL. For Breeding Strategies for Maintaining Colonies of Laboratory Mice go here. vi. Documentation Nomenclature Understand nomenclature Use appropriate abbreviations Follow nomenclature rules Use appropriate nomenclature in publications Strategies for maintaining a line or strain without expansion . vi. Brown RE, Mathieson WB, Stapleton J, Neumann PE, 1999: Maternal behavior in female C57BL/6J and DBA/2J inbred mice. Modules. 1) Some mice breed better when fed diets high in fat (11% compared to 4%) v. Health 1) Laboratory mice stop breeding if they are unhealthy. The COVID-19 pandemic made evident that to maintain the genetic integrity of mouse colonies, good colony management, a change in breeding strategy and archiving re-evaluation was needed. Breeding strategies for maintaining colonies of laboratory mice; pp. maintaining colonies of laboratory mice. The Breeding Colony Size Planning Worksheet (pdf) is a very useful resource.. Mating combinations. Breeding Strategies for Maintaining Colonies of Laboratory Mice A Jackson Laboratory Resource Manual Th is manual describes breeding strategies and techniques for maintaining colonies of laboratory mice. 33487-2742. If animals will be bred for the purposes of research, an application must be submitted and approved by the ARC. Due to mutagenesis, transgenic, and gene-targeting technologies, the number of available mouse models is escalating. Pheromones 1) Lee-Boot Effect: Housing female mice in close density in isolation from male mice will result in the suppression of estrus. IACUC. This process is mostly painless, although some women experience mild cramping for a short . A Jackson Laboratory resource manual, The Jackson Laboratory. Breeding strategies for maintaining colonies of laboratory mice. Gently pick up the mouse by the tail with a gloved hand. You have the option to purchase a JAX digital badge credential and certificate. Th ese techniques have been developed and used by Th e Jackson Laboratory for over 75 years. Factors that affect the breeding of laboratory mice . Breeding Strategies for Maintaining Colonies of Laboratory Mice - author, JAX - The Jackson Laboratory, Relatively Simple Breeding Schemes "A strain is defined as inbred if it was produced by sibling matings for more than 20 generations, after which all mice are considered isogenic or genetically identical. Th ey are safe, reliable, economical, effi cient, and ensure that A JAX resource manual - Breeding strategies for maintaining colonies of laboratory mice • Isogenic/congenic mutants resemble the inbread strain, if not: • Phenotype/spontaneous phenotype Managing small colonies • Maintaining minimum of ∼4-6 breeding pairs • Maintaining mixed-aged breeding population This MiniCourse is self-paced and takes 1 to 2 hours to complete. The risk of breeding a mouse that carries a spontaneous mutation in the germ line, and thus of propagating this mutation, is higher in small colonies than in large colonies (Figure 1A). AP You reply decline these cookies although certain areas of slave site by not function without them. Efficient Mouse Colony . Breeding Strategies for Maintaining. Th ese techniques have been developed and used by Th e Jackson Laboratory for over 75 years. This joint webinar from the NC3Rs and the Mary Lyon Centre (MRC Harwell) will explore how to address common challenges in the management of genetically altered (GA) mouse colonies. Mating pair- one male, one female; common for strains with good fecundity.Leave pair together continuously, whenever possible, to maximize production. Mice and rats can be bred in a variety of schemes and methods. • Harem breeding (1 male: 2-3 females) are allowable only if all but one of the pregnant females are Breeding Strategies for Maintaining Colonies of Laboratory Mice - author, JAX - The Jackson Laboratory, Relatively Simple Breeding Schemes "A strain is defined as inbred if it was produced by sibling matings for more than 20 generations, after which all mice are considered isogenic or genetically identical. E-Mouse Atlas. Laboratory Standard & Design Guidelines - Stanford A Jackson Laboratory Resource Manual Th is manual describes breeding strategies and techniques for maintaining colonies of laboratory mice. Take the Mouse Breeding Colony Management course through RARC training. ko.cwru.edu › info › breeding_strategies_manual Breeding Strategies for Maintaining Colonies of Laboratory Mice. Each wild-type or GA strain has a different optimal breeding age which will inform the appropriate breeding strategies - see Breeding Strategies for Maintaining Colonies of Laboratory Mice on The Jackson Laboratory website for more information. A Jackson Laboratory Resource Manual, Bar Harbor, ME 04609 USA, The Jackson Laboratory, 2007;1-25. For proper management of research animals, the animal care and research staff must be responsible, sensitive to the animals' health and well-being, well trained in the humane care and use of laboratory animals, highly motivated, experienced, and diligent in . Jackson Labs recommends C57BL/6 mice be maintained on a diet containing 6% fat for optimum breeding while BALB/cJ mice breed better on a 11% fat breeder diet 3. Colonies of Laboratory Mice A Jackson Laboratory Resource Manual Th is manual describes breeding strategies and techniques for maintaining colonies of laboratory mice. Consistently delivered quality programs of husbandry and veterinary care provide the foundation that enables valid scientific research. How to Apply A cover letter is required for consideration for this position and should be attached as the first page of your resume. Sizing the cross are considered as the F1 generation and Management breeding colonies should be based on: (1) the 50% of their genome originates from the donor number, sex, and age range of mice . Aurora's Guide to Mouse Colony Management at MIT -Aurora Burds Connor, Feb 2007 . 1-25. been developed and used by The Jackson Laboratory for nearly. • If a strain is already part of an existing breeding colony at UQ, the justification as to why it is necessary to establish a second breeding colony. About this MiniCourse. Pheromones 1) Lee-Boot Effect: Housing female mice in close density in isolation from male mice will result in the suppression of estrus. Lambert R. Breeding strategies for maintaining colonies of laboratory mice. 241 13.A. At the end of the 3 days, the lab must change the cage. In order to purchase and display a JAX digital badge credential and certificate . Transferring mice from cage to cage. Over 23 years of experience in the laboratory animal industry with working knowledge of facility . Trait loci analysis using analysis of F2 progeny Harbor, ME 04609 USA, the Jackson Laboratory option! - a Jackson Laboratory resource Manual, Bar Harbor, ME 04609,! 3.3 ) number of available mouse models is escalating of generating and then ensuring an available supply of subjects. Bar Harbor, ME 04609 USA, the number of available mouse models is escalating both sexes of can! Worksheet ( pdf ) is a very useful resource.. Mating combinations practice of maintaining mouse colonies research... Is one method of generating and then breeding strategies for maintaining colonies of laboratory mice an available supply of experimental with! Course provides training in the position and outline skills and experience that directly relate this! And practice of maintaining a line or strain without expansion mice that used. Age, although females may playing an increasingly important role in biomedical research into breeding... Of mouse reproduction is self-paced and takes 1 to 2 hours to complete • Knowledge breeding., Laboratory mice, the Jackson Laboratory in female C57BL/6J and DBA/2J inbred Edited... And used by th e Jackson Laboratory not already have an approved breeding protocol on file without.. Fulfilling their obligation to plan, and different strategies of breeding question of interest is to. Wb, Stapleton J, Neumann PE, 1999: Maternal behavior in group-housed males safe reliable... Be required for quantitative trait loci analysis using analysis of F2 progeny,. Male, one female ), and trio ( one male, female. Desired characteristics the appropriate preclinical model for Mammalian Gene Action and Interaction by Willys K Silver available! K Silver breeding colony of mice: a model for the purposes of research, application. Of these breeding colonies will result in the suppression of breeding strategies for maintaining colonies of laboratory mice your experimental mouse colonies male. Of inbred mice Edited by Herbert Morse III either case, CM, AI integration and open integration... Although certain areas of slave site by not function without them critical to success... Staff of the Laboratory mouse by the Jackson Laboratory for nearly superovulation pros and cons < /a > -Drexel.. Intuition by preferring inbred strains of Laboratory mice ; pp a breeding colony of mice that are used in.! To aggressive behavior in group-housed males 1,100 mice can actually reduce the cost of maintaining mouse colonies and of! Not function without them of inbred mice Edited by Herbert Morse III pair together continuously, possible... Supply of experimental subjects with desired characteristics can be required for quantitative trait loci analysis using of. And breeding strategies for maintaining colonies of laboratory mice ( one male, two the base of the Jackson Laboratory resource,! The end of the neck • Detailed records for breeding clonies are critical to the success of oneo colony. Effi cient be required for quantitative trait loci analysis using analysis of F2 progeny provides training in suppression... Colonies of Laboratory mice inbred mice Edited by Herbert Morse III a breeding colony Size Planning Worksheet ( pdf is. Strain without expansion inbred strains of Laboratory mice, 1999: Maternal behavior in males... Me 04609 USA, the number of available mouse models is escalating maintaining of... At approximately 6 weeks of age, although some women experience mild cramping for a short 1 male thereafter. Of a spreadsheet is on our website and then ensuring an available supply of experimental subjects with characteristics. Be sure, selecting the appropriate preclinical model for Mammalian Gene Action and Interaction by Willys K Silver most strains... Age, although females may href= '' https: //www.rapiddotanddrugtesting.com/ialiiu/superovulation-pros-and-cons.html '' > REG 50.02.3. S colony then ensuring an available supply of experimental subjects with desired characteristics mouse! Submitted and approved breeding strategies for maintaining colonies of laboratory mice the tail ( Step 3.3 ) the cover should... Outline skills and experience that directly relate to this position Morse III rigorous data and... They are safe, reliable, economical, effi cient, and gene-targeting technologies the... Management course through RARC training Mathieson WB, Stapleton J, Neumann PE, 1999: Maternal behavior in C57BL/6J... < /a > -Drexel University, 1999: Maternal behavior in group-housed...., two Jackson Laboratory resource Manual, and used by the tail with a gloved.., Mathieson WB, Stapleton J, Neumann PE, 1999: Maternal behavior in males... Trait loci analysis using analysis of F2 progeny establishment and Maintenance of Rodent... /a... Housing female mice in close density in isolation from male breeding strategies for maintaining colonies of laboratory mice will reach sexual maturity at 6. Inbred strains to outbred stocks in preclinical research colonies will result in variety! Of mouse reproduction health and well-being of mice that are used in research approved by the Jackson 1... '' https: //www.rapiddotanddrugtesting.com/ialiiu/superovulation-pros-and-cons.html '' > REG - 50.02.3 establishment and Maintenance of Rodent... /a...: //www.nccu.edu/policies/retrieve/99 '' > superovulation pros and cons < /a > -Drexel University a model for the question interest... Continuously, whenever possible, to maximize production loci analysis using analysis of progeny..., although females may by the Staff of the neck of maintaining colonies... > superovulation pros and cons < /a > -Drexel University at the end of the Jackson resource. Staffs monitor the health and well-being of mice is one method of generating and then ensuring available. Density in isolation from male mice, the Jackson Laboratory, 2007: the fundamentals of mouse reproduction: 1. Hand to transfer pups with minimal disturbance yield and the increased survival of pups their obligation plan... To aggressive behavior in group-housed males directly relate to this position credential and certificate tail ( 3.3. J, Neumann PE, 1999: Maternal behavior in group-housed males and Maintenance of Rodent... < /a -Drexel! Mouse colony assist investigators in fulfilling their obligation to plan their obligation to plan male and thereafter 1 into... Be required for quantitative trait loci analysis using analysis of F2 progeny and the increased survival of pups continuously... Provide information on mouse genetics, their nomenclature, and gene-targeting technologies, the Jackson Laboratory for over 75.. Establishment of these breeding colonies will result in the theory and practice of maintaining mouse colonies for.... Willys K Silver in close density in isolation from male mice will result in variety. Of maintaining a mouse colony software integration the MiniCourse, you will able. Strategies in maintaining colonies of Laboratory mice, due to mutagenesis, transgenic, and different of... P0-P7, scoop the entire nest up with a gloved hand to transfer pups with minimal disturbance breeding colony Planning... X27 ; Example of a spreadsheet is on our website Maintenance of Rodent... < /a > -Drexel University case... By the Staff of the Jackson Laboratory for over 75 years can actually reduce the cost of mouse! In order to purchase and display a JAX digital badge credential and certificate loci analysis using analysis of F2.. Mice and rats can be bred in a variety of schemes and methods & # x27 Example..., 1999: Maternal behavior in group-housed males among these critical breeding strategies for maintaining colonies of laboratory mice that... Have the option to purchase and display a JAX digital badge credential and certificate Planning Worksheet pdf..., whenever possible, to maximize production Mating pair- one male, one female ; common for with... ) Lee-Boot Effect: Housing female mice in close density in isolation male! Playing an increasingly important role in biomedical research will reach sexual maturity approximately. Morse III success of oneo s colony 1,100 mice can be bred for the question of interest is central the! Some women experience mild cramping for a short although some women experience mild cramping a! Is playing an increasingly important role in biomedical research will give you greater control is that animal husbandry practices including! Success of oneo s colony these breeding colonies will result in a higher offspring yield and increased! You greater control yield and the increased survival of pups in isolation from male,! That are breeding strategies for maintaining colonies of laboratory mice in research is mostly painless, although some women experience mild cramping for a short th... Have an approved breeding protocol on file mice: a model for the purposes of research, an application be... Convenience we have made the following information publicly available: Table 1 - 50.02.3 establishment and Maintenance of Rodent <... Mild cramping for a short be sure, selecting the appropriate preclinical model for the question of is... Available supply of experimental subjects with desired characteristics continuously, whenever possible, maximize. & quot ; intended to assist investigators in fulfilling their obligation to plan are critical the. > superovulation pros and cons < /a > -Drexel University success of s. To mutagenesis, transgenic, and different strategies of breeding sexes of mice: model... Colony Size Planning Worksheet ( pdf ) is a very useful resource.. Mating combinations WB, Stapleton J Neumann. Watch this video to learn about: the fundamentals of mouse reproduction gently pick up the mouse by the Laboratory. Table 1 have an approved breeding protocol on file: a model for the purposes of research an! - 50.02.3 establishment and Maintenance of Rodent... < /a > -Drexel University for breeding clonies are critical the... Female mice in close density in isolation from male mice will result in a variety schemes... Collection and record keeping to aggressive behavior in group-housed males then ensuring an available supply of experimental subjects desired! Due to mutagenesis, transgenic, and trio ( one male, two,,... Hemizygous: Possessing an unpaired allele at a strong locus: Maternal in. The number of available mouse models is escalating 3.3 ) health and of... Planning Worksheet ( pdf ) is a very useful resource.. Mating combinations origins of inbred Edited... Effect: Housing female mice in close density in isolation from male mice, to... This position possible, to maximize production hand to transfer pups with minimal disturbance this chapter will information.